Scientist, Genomics and Cancer Biology

Location: United States Position Summary We are seeking a Scientist to drive multimodal genomics experiments supporting external BioPharma collaborations and internal discovery efforts. The Scientist will design, execute, and interpret studies that combine bulk and single-cell epigenomic and transcriptomic, spatial transcriptomic, and proteomic (including spatial proteomic) readouts on preclinical models and human patient samples, translating complex datasets into biological insight for pharma partners and internal programs. This is a hands-on, independent-contributor role for a scientist early in their industry career who combines strong cancer-biology judgment with technical depth across multiple genomic platforms and is comfortable working with computational scientists and project teams. Key Responsibilities • Drive end-to-end execution of multimodal genomics studies (e.g., DNA methylation/hydroxymethylation, chromatin accessibility and occupancy, RNA-seq, proteomics/phosphoproteomics) from experimental design through data delivery. • Plan and execute single-cell RNA-seq, spatial transcriptomics, and spatial proteomics experiments, including sample preparation, platform workflows, QC, and coordination with computational scientists for downstream analysis of cell types, states, and tissue architecture. • Translate collaborator and program questions (e.g., mechanism of action, therapeutic response, biomarker discovery) into fit-for-purpose experimental designs, sample plans, and assay panels. • Support external BioPharma collaborations: contribute to study scoping, execute studies to agreed timelines, communicate progress and results to partners, and contribute to reports and presentations. • Lead internal discovery experiments that generate and test hypotheses about cancer cell state, treatment response, and candidate biomarkers, including potential application to liquid-biopsy (cfDNA/ctDNA) profiling. • Generate high-quality NGS and, where applicable, mass-spectrometry datasets; perform library preparation, QC, and sequencing run management, and flag technical or batch effects. • Integrate multi-modal datasets using R and/or Python, in partnership with computational scientists, to identify signatures and prioritize candidates. • Implement and standardize laboratory workflows, including liquid-handling automation, to improve throughput and reproducibility across projects. • Maintain rigorous documentation, sample tracking, and data provenance; contribute to SOPs, technical reports, manuscripts, and patents. • Mentor and train junior staff and collaborators in experimental design and technical methods as needed. Minimum Qualifications • Ph.D. in Cancer Biology, Molecular Biology, Genetics/Genomics, Biochemistry, or a related field. • Plus ONE of the following: (a) at least 1 year of relevant industry experience (biotech, pharma, diagnostics, or equivalent), or (b) a completed postdoctoral fellowship. • Demonstrated experience with at least two genomic modalities (e.g., epigenomic sequencing, RNA-seq, proteomics) and with NGS library preparation and QC as evidenced in high quality publications. • Working proficiency in R and/or Python for genomic data analysis and visualization. • Demonstrated ability to work across wet-lab and computational teams, and to communicate results clearly in writing and verbally. • Strong desire to drive the utilization of novel technological approaches to answer difficult biological questions. Preferred Qualifications • Hands-on experience with single-cell RNA-seq, spatial transcriptomics and/or spatial proteomics platforms (e.g., sequencing-based or imaging-based spatial assays, multiplexed tissue imaging), including FFPE or fresh-frozen tissue handling. • Familiarity with other high-dimensional platforms such as quantitative mass spectrometry. • Experience with human patient tissue and preclinical models (cell lines, organoids, GEMMs). • Familiarity with functional assays (flow cytometry, viability, live-cell imaging, protein-interaction and kinase assays). • Experience working in a collaborative environment. • Ability to manage timelines and deliverables across multiple concurrent projects. Core Competencies • Scientific independence and sound experimental design across multiple platforms • Rigor in data quality, controls, and distinguishing signal from artifact • Collaboration with wet-lab, computational, and project-management colleagues • Clear communication of complex data to technical and non-technical (including pharma) audiences • Prioritization and reliable delivery against partner and program timelines • Excellent presentation and writing skills The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations. Remote USA $101,400—$126,700 USD Compensation & Total Rewards This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations. This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including: Annual performance incentive bonus Long-term equity awards Comprehensive health benefits (medical, dental, vision) 401(k) with company match Generous paid time off and company holidays Additional wellness and work-life benefits Compensation Range $101,400—$126,700 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits